Jeff Purslow, PhD

Education:

2022- Alexander Von Humboldt Postdoctoral Research Fellow at Max Planck Institute for Multidisciplinary Sciences (MPI-NAT) and German Center for Neurodegenerative Diseases (DZNE)

2021-PhD, Chemistry, Iowa State University 

2015-BS, Chemistry, Worcester State University

2013-AA & AS, Williston State College

Publications:

1. Khatiwada, B., Nguyen, T.T., Purslow, J.A., & Venditti, V. (2022). Solution structure ensemble of human obesity-associated protein FTO reveals druggable surface pockets at the interface between the N- and C-terminal domain. J. Biol. Chem. 298 (5).
2. Purslow, J.A., Nguyen, T.T., Khatiwada, B., Singh, A., & Venditti, V. (2021). N6-methyladenosine binding induces a metal-centered rearrangement that activates the human RNA demethylase Alkbh5. Sci. Adv. 7, eabi8215.
3. Purslow, J.A., Thimmesch, J.N., Sivo, V., Nguyen, T.T., Khatiwada, B., Dotas, R.R., & Venditti, V. (2021). A single point mutation controls the rate of interconversion between the g+ and g- rotamers of the Histidine 189 Χ2 angle that activates bacterial Enzyme I for catalysis. Front. Mol. Biosci. 8, 699203.
4. Singh, A., Purslow, J. A., Venditti, V. 15N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the µs-ms Timescale. J. Vis. Exp. (170), e62395, DOI:10.3791/62395 (2021).
5. Purslow JA, Khatiwada B, Bayro MJ and Venditti V (2020) NMR Methods for Structural Characterization of Protein-Protein Complexes. Front. Mol. Biosci. 7:9. DOI: 10.3389/fmolb.2020.00009.
6. Khatiwada, B., Purslow, J.A., Underbakke, E.S., Venditti, V. Protein Expr. Purif. 167 (2020) 105540. DOI: 10.1016/j.pep.2019.105540.
7. Purslow JA, Nguyen TT, Egner TK, Dotas RR, Khatiwada B, Venditti V. Biophys J. 2018 Nov 20;115(10):1895-1905. DOI: 10.1016/j.bpj.2018.10.004.
8. Purslow, J.A. & Venditti, V. Biomol NMR Assign (2018). https://doi.org/10.1007/s12104-018-9826-3.
9. Clark, K.D., Purslow, J.A., Pierson, S.A., Nacham, O., Anderson, J.L. Rapid Preconcentration of Viable Bacteria using Magnetic Ionic Liquids for PCR Amplification and Culture-based Diagnostics, Analytical and Bioanalytical Chemistry, 2017, 409, 4983-4991. DOI: 10.1007/s00216-017-0439-y.
10. Clark, K. D., Nacham, O., Purslow, J. A., Pierson, S. A., & Anderson, J. L. (2016). Magnetic ionic liquids in analytical chemistry: A review. Analytica Chimica Acta, 934, 9-21. DOI: 10.1016/j.aca.2016.06.011